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Helena Bioinformatics

Helena Bioinformatics is a Bulgarian bioinformatics and scientific software company headquartered in Sofia. The company develops computational methods, genomic data infrastructure and digital research platforms for genetics laboratories, biomedical researchers, universities and organisations working with genomic and clinical evidence. Its principal product, Folklore, supports genomic variant interpretation for gene panels, whole-exome sequencing and whole-genome sequencing. The platform brings together variant annotation, classification evidence, phenotype matching, inheritance analysis, literature references and prioritisation within a structured case-review workflow. Its software-assisted results are intended for review and interpretation by qualified genetics professionals. Helena also develops Undertone, a genome-wide association study (GWAS) interpretation platform that supports locus discovery, fine-mapping, candidate gene identification, tissue analysis and biological mechanism hypotheses. Its Noodle platform provides semantic biomedical literature discovery, publication exploration and research discussion tools. Evidence, another Helena product, presents versioned scientific studies with methods, source data, results and interactive sensitivity analyses. The company also works on computational genomics research, deterministic variant classification methods, evidence provenance, reproducible analysis and high-performance genomic processing infrastructure. Its activities include software development, laboratory workflow integration, research collaboration, technical validation and partnerships with laboratory and technology organisations. Based in Bulgaria, Helena Bioinformatics focuses commercially on European genetics laboratories, with the Balkans as its initial regional market. Its scientific and software platforms support professional genomic research and evidence review. Clinical decisions and final interpretation remain the responsibility of appropriately qualified professionals, and regulated clinical-use capabilities depend on their applicable validation and authorisation status.

Sofia, Bulgaria

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